- In insects, mimics the neurotransmitter acetylcholine, which activates nerve impulses at the synapse receptor.
- Contrary to acetylcholine whose effects are terminated very fast, dinotefuran is not susceptible to synaptic enzymes. Dinotefuran binds permanently and causes continuous nerve stimulation.
- Dinotefuran causes paralysis and death to insects.
- Kills fleas by contact; ingestion is not required.
- After application, this compound adheres to the skin surface and hair of dogs and puppies.
- Does not bind to mammalian acetylcholine receptor sites.
- Exclusive active to Ceva in the EU and US.
- Extremely potent, long-lasting and photostable.
- Targets the reproduction and development of insects such as fleas. Sterilises adult fleas, kills larvae and prevents emergence of new adults.
- Mimics the growth hormone (Juvenile Hormone) regulating when the insect molts and moves to the next life stage.
- Normally, the JH breaks down over time, allowing the molting, but Pyriproxyfen keeps the hormone level too high to allow the molt, and they eventually die.
- Is a synthetic pyrethroid.
- Repels and knock-down the parasites
- Insecticide and acaricide which targets the nervous system of arthropods
- During a nerve impulse, voltage-gated sodium channels open, causing depolarisation of the nerve.
- Permethrin binds to this gate protein and prevents it from closing normally.
- This causes repetitive activity in the sensory and motor pathways, causing tremors.
- Parasites lose control of their nervous system, are unable to produce coordinated movement and die.